OralVive® hyaluronic acid (HA) Veterinary Dental Gel

OralVive^® is a veterinary dental gel formulated with hyaluronic acid (HA) and Poloxymer gel designed to support oral tissue healing, reduce inflammation, and enhance periodontal health in companion animals. Poloxamer provides the smart gel behavior, while HA provides adhesion, hydration, and biological interaction. Together, they form an ideal mucoadhesive hydrogel system that improves both retention and absorption.

Hyaluronic acid is a naturally occurring glycosaminoglycan present in connective, epithelial, and neural tissues. In the oral cavity, it contributes to extracellular matrix integrity, tissue hydration, and cellular signalling processes critical for wound healing and angiogenesis.

Poloxamer gel is a water-based solution of PEO–PPO–PEO triblock copolymers that forms a gel when warmed to body temperature. Its unique structure gives it biocompatibility, reversibility, and versatility for medical and veterinary applications.

In veterinary dentistry, HA is applied to promote healing and reduce inflammation in oral tissues. It can be used:

• After dental cleanings or extractions
• In cases of gingivitis or periodontitis
• As a topical gel to improve gum health and tissue regeneration

• Enhanced wound healing: Promotes tissue repair by supporting fibroblast migration and collagen formation.
• Anti-inflammatory effect: Reduces swelling and discomfort after dental procedures.
• Improved tissue hydration: Maintains a moist environment that supports healing.
• Antibacterial barrier: Forms a protective film that can reduce bacterial adherence.
• Gingival regeneration: Encourages recovery of gingival tissue after periodontal therapy.

• High bioadhesion which means it will adhere to and stay in the location better
• The formulation stays longer on the mucosal surface instead of dripping or being washed away quickly.
• Contact time with epithelial cells is extended → more absorption opportunity.
• Controlled and prolonged release, often improving local and sometimes systemic bioavailability.
• Improved uptake without damaging mucosa

OralVive^® is formulated primarily for dogs and cats, though it may also be considered for other small mammals and exotic species under veterinary discretion.

OralVive^® is indicated as an adjunctive therapy for:

• Post-scaling, polishing, or periodontal procedures
• Gingivitis and periodontitis management
• Post-extraction or oral surgery care
• Ulcerative or traumatic lesions of the oral mucosa
• Maintenance of oral tissue health in predisposed patients (e.g., brachycephalic breeds, geriatric animals)

When applied to the gums or oral tissue, OralVive^® forms a protective gel that:

• Hydrates and conditions the mucosa
• Supports natural wound healing and tissue regeneration
• Reduces inflammation and discomfort
• Creates a barrier that helps limit bacterial adhesion

OralVive^® is applied using a 3ml luer lock syringe and tip topically as a gel directly to the gums and oral mucosa or applied subgingivally and into periodontal pockets and alveolar sockets.

OralVive^® contains biocompatible, non-animal-derived hyaluronic acid and Poloxymer gel. It is non-cytotoxic, non-sensitizing, and safe for mucosal application. Adverse reactions are rare and typically limited to local irritation in the presence of severe infection or contamination.

No. HA is a supportive therapy — not a substitute for mechanical plaque removal or professional dental cleaning. It enhances outcomes but must be combined with regular dental care and home hygiene practices.

HA should not be applied to heavily infected, necrotic, or contaminated wounds without proper cleaning. Use caution with products containing additives or preservatives that are not approved for veterinary oral use.